Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.

Owen, M R

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. [electronic resource] - The Biochemical journal Jun 2000 - 607-14 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0264-6021


Animals
Electron Transport--drug effects
Electron Transport Complex I
Gluconeogenesis--drug effects
Hypoglycemic Agents--pharmacology
Liver--drug effects
Male
Metformin--pharmacology
Mitochondria--drug effects
NADH, NADPH Oxidoreductases--antagonists & inhibitors
Rats
Rats, Wistar
Signal Transduction
Submitochondrial Particles--enzymology
Tumor Cells, Cultured