Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire.

Ferrand, C

Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire. [electronic resource] - Human gene therapy May 2000 - 1151-64 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1043-0342

10.1089/10430340050015202 doi


CD28 Antigens--metabolism
CD4-Positive T-Lymphocytes--metabolism
CD8-Positive T-Lymphocytes--metabolism
Cell Line
DNA, Complementary--metabolism
Gene Transfer Techniques
Genes, T-Cell Receptor beta--genetics
Humans
Immunoglobulin Variable Region--genetics
Immunosuppressive Agents--pharmacology
Interleukin-2--pharmacology
Kinetics
Leukocytes, Mononuclear--metabolism
Muromonab-CD3--pharmacology
Oligonucleotides--metabolism
RNA--metabolism
Retroviridae--genetics
Reverse Transcriptase Polymerase Chain Reaction
T-Lymphocytes--metabolism
Time Factors
Transduction, Genetic