Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.
Schmidt, A
Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. [electronic resource] - Biochemistry May 2000 - 6325-35 p. digital
Publication Type: Journal Article
0006-2960
10.1021/bi992734y doi
Amino Acid Sequence
Aminohydrolases--antagonists & inhibitors
Animals
Binding Sites
Crystallography, X-Ray
Drosophila
Escherichia coli--enzymology
Folic Acid Antagonists--chemistry
Humans
Methylenetetrahydrofolate Dehydrogenase (NADP)--antagonists & inhibitors
Mice
Models, Molecular
Molecular Sequence Data
Multienzyme Complexes--antagonists & inhibitors
Mutagenesis, Site-Directed
NADP--metabolism
Protein Conformation
Rats
Recombinant Proteins--antagonists & inhibitors
Sequence Alignment
Sequence Homology, Amino Acid
Structure-Activity Relationship
Tetrahydrofolates--chemistry
Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. [electronic resource] - Biochemistry May 2000 - 6325-35 p. digital
Publication Type: Journal Article
0006-2960
10.1021/bi992734y doi
Amino Acid Sequence
Aminohydrolases--antagonists & inhibitors
Animals
Binding Sites
Crystallography, X-Ray
Drosophila
Escherichia coli--enzymology
Folic Acid Antagonists--chemistry
Humans
Methylenetetrahydrofolate Dehydrogenase (NADP)--antagonists & inhibitors
Mice
Models, Molecular
Molecular Sequence Data
Multienzyme Complexes--antagonists & inhibitors
Mutagenesis, Site-Directed
NADP--metabolism
Protein Conformation
Rats
Recombinant Proteins--antagonists & inhibitors
Sequence Alignment
Sequence Homology, Amino Acid
Structure-Activity Relationship
Tetrahydrofolates--chemistry