Lack of interaction between tolcapone and tolbutamide in healthy volunteers.

Jorga, K M

Lack of interaction between tolcapone and tolbutamide in healthy volunteers. [electronic resource] - Journal of clinical pharmacology May 2000 - 544-51 p. digital

Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial

0091-2700

10.1177/00912700022009161 doi


Administration, Oral
Adult
Area Under Curve
Aryl Hydrocarbon Hydroxylases
Benzophenones--adverse effects
Blood Glucose--drug effects
Cross-Over Studies
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--metabolism
Drug Interactions
Enzyme Inhibitors--adverse effects
Glucose--pharmacokinetics
Headache--chemically induced
Humans
Hypoglycemia--chemically induced
Hypoglycemic Agents--metabolism
Infusions, Intravenous
Male
Nitrophenols
Single-Blind Method
Steroid 16-alpha-Hydroxylase
Steroid Hydroxylases--antagonists & inhibitors
Tolbutamide--blood
Tolcapone