Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
Wellington, C L
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. [electronic resource] - The Journal of biological chemistry Jun 2000 - 19831-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M001475200 doi
Amino Acid Sequence
Animals
Apoptosis--drug effects
Binding Sites
Blotting, Western
Carcinogens--pharmacology
Caspase 3
Caspase 6
Caspase Inhibitors
Caspases--metabolism
Cell Line
Enzyme Activation--genetics
Fluorescent Antibody Technique
Humans
Huntingtin Protein
Molecular Sequence Data
Mutagenesis
Nerve Tissue Proteins--genetics
Neurons--metabolism
Nuclear Proteins--genetics
Peptides--metabolism
Plasmids--metabolism
Rats
Tamoxifen--pharmacology
Time Factors
Transfection
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. [electronic resource] - The Journal of biological chemistry Jun 2000 - 19831-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M001475200 doi
Amino Acid Sequence
Animals
Apoptosis--drug effects
Binding Sites
Blotting, Western
Carcinogens--pharmacology
Caspase 3
Caspase 6
Caspase Inhibitors
Caspases--metabolism
Cell Line
Enzyme Activation--genetics
Fluorescent Antibody Technique
Humans
Huntingtin Protein
Molecular Sequence Data
Mutagenesis
Nerve Tissue Proteins--genetics
Neurons--metabolism
Nuclear Proteins--genetics
Peptides--metabolism
Plasmids--metabolism
Rats
Tamoxifen--pharmacology
Time Factors
Transfection