Dexamethasone makes the gastric mucosa susceptible to ulceration by inhibiting prostaglandin synthetase and peroxidase--two important gastroprotective enzymes.

Bandyopadhyay, U

Dexamethasone makes the gastric mucosa susceptible to ulceration by inhibiting prostaglandin synthetase and peroxidase--two important gastroprotective enzymes. [electronic resource] - Molecular and cellular biochemistry Dec 1999 - 31-6 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0300-8177

10.1023/a:1007018212822 doi


Animals
Cimetidine--pharmacology
Cyclooxygenase Inhibitors--pharmacology
Dexamethasone--pharmacology
Gastric Acid--metabolism
Gastric Mucosa--drug effects
Histamine Release--drug effects
Imidazoles--pharmacology
Male
Pepsin A--analysis
Peroxidases--antagonists & inhibitors
Prostaglandin-Endoperoxide Synthases--metabolism
Rats
Rats, Wistar
Stomach Ulcer--etiology