Inhibition of CD3/CD28-mediated activation of the MEK/ERK signaling pathway represses replication of X4 but not R5 human immunodeficiency virus type 1 in peripheral blood CD4(+) T lymphocytes.

Popik, W

Inhibition of CD3/CD28-mediated activation of the MEK/ERK signaling pathway represses replication of X4 but not R5 human immunodeficiency virus type 1 in peripheral blood CD4(+) T lymphocytes. [electronic resource] - Journal of virology Mar 2000 - 2558-66 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0022-538X

10.1128/jvi.74.6.2558-2566.2000 doi


Biological Transport
Butadienes--pharmacology
CD28 Antigens--metabolism
CD3 Complex--metabolism
CD4 Antigens--metabolism
CD4-Positive T-Lymphocytes--cytology
Cell Nucleus--metabolism
Cells, Cultured
DNA, Viral--metabolism
Down-Regulation
Enzyme Activation
Enzyme Inhibitors--pharmacology
HIV-1--drug effects
Humans
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors
Nitriles--pharmacology
Proviruses--genetics
Receptors, CXCR4--metabolism
Transcription, Genetic
Virus Integration
Virus Replication--drug effects