Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes.

Chu, I

Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes. [electronic resource] - Rapid communications in mass spectrometry : RCM 2000 - 207-14 p. digital

Publication Type: Journal Article

0951-4198

10.1002/(SICI)1097-0231(20000229)14:4<207::AID-RCM863>3.0.CO;2-# doi


Atmospheric Pressure
Chromatography, High Pressure Liquid--methods
Cytochrome P-450 CYP2D6--analysis
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--analysis
Dextrorphan--chemistry
Drug Design
Drug Evaluation, Preclinical
Enzyme Inhibitors--chemistry
Evaluation Studies as Topic
Humans
Hydroxytestosterones--chemistry
In Vitro Techniques
Mass Spectrometry--methods
Microsomes, Liver--enzymology
Mixed Function Oxygenases--analysis
Reproducibility of Results
Substrate Specificity