Identification of beta-secretase-like activity using a mass spectrometry-based assay system.

Grüninger-Leitch, F

Identification of beta-secretase-like activity using a mass spectrometry-based assay system. [electronic resource] - Nature biotechnology Jan 2000 - 66-70 p. digital

Publication Type: Journal Article

1087-0156

10.1038/71944 doi


Amino Acid Sequence
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor--genetics
Animals
Aspartic Acid Endopeptidases--chemistry
Cathepsin D--chemistry
Cathepsin E--genetics
Cell Extracts--chemistry
Cell Line
Ceramics
Endopeptidases
Humans
Metalloendopeptidases--metabolism
Mice
Microspheres
Molecular Sequence Data
Molecular Weight
Mutation--genetics
Pepstatins--metabolism
Peptide Fragments--chemistry
Rats
Recombinant Fusion Proteins--chemistry
Reproducibility of Results
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization--methods
Substrate Specificity
Sweden
Transfection