Correlation of the intrinsic clearance of donepezil (Aricept) between in vivo and in vitro studies in rat, dog and human.

Matsui, K

Correlation of the intrinsic clearance of donepezil (Aricept) between in vivo and in vitro studies in rat, dog and human. [electronic resource] - Xenobiotica; the fate of foreign compounds in biological systems Nov 1999 - 1059-72 p. digital

Publication Type: Comparative Study; Journal Article

0049-8254

10.1080/004982599237958 doi


Administration, Oral
Algorithms
Animals
Biotransformation
Blood Proteins--metabolism
Cholinesterase Inhibitors--administration & dosage
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Dogs
Donepezil
Female
Humans
In Vitro Techniques
Indans--administration & dosage
Injections, Intravenous
Kinetics
Male
Microsomes, Liver--metabolism
Piperidines--administration & dosage
Protein Binding
Rats
Rats, Sprague-Dawley
Species Specificity