Distinct role of cAMP and cGMP in the cell cycle control of vascular smooth muscle cells: cGMP delays cell cycle transition through suppression of cyclin D1 and cyclin-dependent kinase 4 activation.

Fukumoto, S

Distinct role of cAMP and cGMP in the cell cycle control of vascular smooth muscle cells: cGMP delays cell cycle transition through suppression of cyclin D1 and cyclin-dependent kinase 4 activation. [electronic resource] - Circulation research Nov 1999 - 985-91 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0009-7330

10.1161/01.res.85.11.985 doi


8-Bromo Cyclic Adenosine Monophosphate--pharmacology
Blotting, Western
CDC2-CDC28 Kinases
Cell Cycle--drug effects
Cells, Cultured
Cyclic AMP--pharmacology
Cyclic GMP--analogs & derivatives
Cyclin D1--antagonists & inhibitors
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinases--antagonists & inhibitors
Cyclins--physiology
Enzyme Activation--drug effects
Humans
Muscle, Smooth, Vascular--cytology
Phosphorylation--drug effects
Protein Processing, Post-Translational--drug effects
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins
Umbilical Arteries