Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis.

Shaheen, R M

Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. [electronic resource] - Cancer research Nov 1999 - 5412-6 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0008-5472


Animals
Apoptosis
Colonic Neoplasms--drug therapy
Endothelium--drug effects
Fluorescent Antibody Technique
In Situ Nick-End Labeling
Indoles--pharmacology
Liver Neoplasms--drug therapy
Male
Mice
Mice, Inbred BALB C
Neovascularization, Pathologic--drug therapy
Pyrroles--pharmacology
Random Allocation
Receptor Protein-Tyrosine Kinases--drug effects
Receptors, Growth Factor--drug effects
Receptors, Vascular Endothelial Growth Factor
Tumor Cells, Cultured