Binding of polyomavirus small T antigen to protein phosphatase 2A is required for elimination of p27 and support of S-phase induction in concert with large T antigen.

Schüchner, S

Binding of polyomavirus small T antigen to protein phosphatase 2A is required for elimination of p27 and support of S-phase induction in concert with large T antigen. [electronic resource] - Journal of virology Nov 1999 - 9266-73 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-538X

10.1128/JVI.73.11.9266-9273.1999 doi


3T3 Cells
Animals
Antigens, Polyomavirus Transforming--metabolism
CDC2-CDC28 Kinases
Cell Cycle Proteins
Cyclin A--biosynthesis
Cyclin E--biosynthesis
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases--antagonists & inhibitors
Enzyme Inhibitors--metabolism
Mice
Microtubule-Associated Proteins--metabolism
Phosphoprotein Phosphatases--metabolism
Phosphoric Monoester Hydrolases--metabolism
Phosphorylation
Plasmids--genetics
Polyomavirus--immunology
Precipitin Tests
Protein Kinases
Protein Phosphatase 2
Protein Serine-Threonine Kinases--antagonists & inhibitors
S Phase
Transfection
Tumor Suppressor Proteins