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Peroxynitrite inactivates tryptophan hydroxylase via sulfhydryl oxidation. Coincident nitration of enzyme tyrosyl residues has minimal impact on catalytic activity.

Kuhn, D M

Peroxynitrite inactivates tryptophan hydroxylase via sulfhydryl oxidation. Coincident nitration of enzyme tyrosyl residues has minimal impact on catalytic activity. [electronic resource] - The Journal of biological chemistry Oct 1999 - 29726-32 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

ISSN: 0021-9258

Standard No.: 10.1074/jbc.274.42.29726 doi

Subjects--Topical Terms:
Catalysis
Kinetics
Nitrates--metabolism
Sulfhydryl Compounds--chemistry
Tetranitromethane--pharmacology
Tryptophan Hydroxylase--chemistry

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