WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.

Bolognesi, M L

WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors. [electronic resource] - Journal of medicinal chemistry Oct 1999 - 4214-24 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm991065j doi


Adrenergic alpha-Agonists--chemical synthesis
Adrenergic alpha-Antagonists--chemical synthesis
Animals
Aorta, Thoracic--drug effects
CHO Cells
Cloning, Molecular
Cricetinae
Dioxanes--chemical synthesis
HeLa Cells
Humans
In Vitro Techniques
Male
Muscle Contraction--drug effects
Muscle, Smooth--drug effects
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, alpha-1--drug effects
Receptors, Serotonin--drug effects
Receptors, Serotonin, 5-HT1
Serotonin Antagonists--chemical synthesis
Serotonin Receptor Agonists--chemical synthesis
Spleen--drug effects
Stereoisomerism
Structure-Activity Relationship
Vas Deferens--drug effects