Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.

James, S J

Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. [electronic resource] - The American journal of clinical nutrition Oct 1999 - 495-501 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0002-9165

10.1093/ajcn/70.4.495 doi


Adult
Alcohol Drinking--adverse effects
Case-Control Studies
Chromatography, High Pressure Liquid
DNA--chemistry
Deoxyribonucleases, Type II Site-Specific--chemistry
Diet Surveys
Diet, Reducing--adverse effects
Dietary Supplements
Down Syndrome--genetics
Electrophoresis, Agar Gel
Female
Folic Acid--administration & dosage
Genotype
Homocysteine--blood
Humans
Methionine--blood
Methotrexate--pharmacology
Methylenetetrahydrofolate Reductase (NADPH2)
Oxidoreductases Acting on CH-NH Group Donors--genetics
Point Mutation
Polymerase Chain Reaction
Risk Factors
Surveys and Questionnaires