Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole.

Verdoodt, B

Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole. [electronic resource] - Mutagenesis Sep 1999 - 513-20 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0267-8357

10.1093/mutage/14.5.513 doi


Adult
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Survival--drug effects
Cells, Cultured
Demecolcine--pharmacology
Dose-Response Relationship, Drug
Gene Expression
Humans
In Situ Nick-End Labeling
K562 Cells
Leukemia--genetics
Lymphocytes--cytology
Nocodazole--pharmacology
Phytohemagglutinins--pharmacology
Polyploidy
Spindle Apparatus--drug effects
Time Factors
Tumor Cells, Cultured
Tumor Suppressor Protein p53--genetics