Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway.

Rousseau, D

Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway. [electronic resource] - Oncogene Jul 1999 - 4313-25 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0950-9232

10.1038/sj.onc.1202686 doi


3T3 Cells
Acetylcysteine--analogs & derivatives
Animals
CDC2-CDC28 Kinases
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinases--immunology
Cyclins--genetics
Cycloheximide--pharmacology
Cysteine Endopeptidases--metabolism
Cysteine Proteinase Inhibitors--pharmacology
Gene Deletion
Gene Expression Regulation, Neoplastic
Growth Inhibitors
Hemagglutinins--immunology
Humans
Leupeptins--pharmacology
Mice
Models, Genetic
Multienzyme Complexes--metabolism
Mutagenesis
Osteosarcoma--metabolism
Proliferating Cell Nuclear Antigen--metabolism
Proteasome Endopeptidase Complex
Protein Serine-Threonine Kinases--immunology
Protein Synthesis Inhibitors--pharmacology
Time Factors
Transfection
Tumor Cells, Cultured
Ubiquitins--metabolism