Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
Wessel, I
Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform. [electronic resource] - Cancer research Jul 1999 - 3442-50 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0008-5472
Adenosine Triphosphate--metabolism
Amino Acid Sequence
Amino Acid Substitution
Amsacrine--pharmacology
Animals
Antineoplastic Agents--chemistry
Binding Sites
CHO Cells
Carcinoma, Small Cell--drug therapy
Catalysis--drug effects
Consensus Sequence
Cricetinae
Cricetulus
DNA Damage
DNA Mutational Analysis
DNA Topoisomerases, Type II--genetics
DNA, Neoplasm--genetics
DNA, Single-Stranded--genetics
Drug Resistance, Neoplasm--genetics
Enzyme Inhibitors--pharmacology
Etoposide--pharmacology
Humans
Lung Neoplasms--drug therapy
Molecular Sequence Data
Mutagenesis, Site-Directed
Point Mutation
Protein Isoforms--antagonists & inhibitors
Razoxane--chemistry
Recombinant Fusion Proteins--metabolism
Saccharomyces cerevisiae--genetics
Structure-Activity Relationship
Thiobarbiturates--pharmacology
Topoisomerase II Inhibitors
Tumor Stem Cell Assay
Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform. [electronic resource] - Cancer research Jul 1999 - 3442-50 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0008-5472
Adenosine Triphosphate--metabolism
Amino Acid Sequence
Amino Acid Substitution
Amsacrine--pharmacology
Animals
Antineoplastic Agents--chemistry
Binding Sites
CHO Cells
Carcinoma, Small Cell--drug therapy
Catalysis--drug effects
Consensus Sequence
Cricetinae
Cricetulus
DNA Damage
DNA Mutational Analysis
DNA Topoisomerases, Type II--genetics
DNA, Neoplasm--genetics
DNA, Single-Stranded--genetics
Drug Resistance, Neoplasm--genetics
Enzyme Inhibitors--pharmacology
Etoposide--pharmacology
Humans
Lung Neoplasms--drug therapy
Molecular Sequence Data
Mutagenesis, Site-Directed
Point Mutation
Protein Isoforms--antagonists & inhibitors
Razoxane--chemistry
Recombinant Fusion Proteins--metabolism
Saccharomyces cerevisiae--genetics
Structure-Activity Relationship
Thiobarbiturates--pharmacology
Topoisomerase II Inhibitors
Tumor Stem Cell Assay