Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.

Kim, H

Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells. [electronic resource] - Molecular and cellular biology Aug 1999 - 5326-38 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.

0270-7306

10.1128/MCB.19.8.5326 doi


Acute-Phase Proteins--biosynthesis
Acute-Phase Reaction--genetics
Adaptor Proteins, Signal Transducing
Animals
Antigens, CD--physiology
Calcium-Calmodulin-Dependent Protein Kinases--physiology
Carcinoma, Hepatocellular--genetics
Cytokine Receptor gp130
DNA-Binding Proteins--physiology
Enzyme Activation
GRB2 Adaptor Protein
Gene Expression Regulation
Gene Expression Regulation, Neoplastic
Humans
Interleukin-6--physiology
Intracellular Signaling Peptides and Proteins
Janus Kinase 1
Liver--drug effects
Liver Neoplasms--genetics
Liver Neoplasms, Experimental--genetics
Membrane Glycoproteins--physiology
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases
Neoplasm Proteins--biosynthesis
Phosphorylation
Protein Processing, Post-Translational
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases--physiology
Protein-Tyrosine Kinases--physiology
Proteins--metabolism
Rats
Receptors, Interleukin-6--drug effects
Recombinant Fusion Proteins--physiology
SH2 Domain-Containing Protein Tyrosine Phosphatases
STAT3 Transcription Factor
Signal Transduction--physiology
Trans-Activators--physiology
Transcription, Genetic
Transcriptional Activation
Transfection