Multiple promoter elements are required for the stimulatory effect of insulin on human collagenase-1 gene transcription. Selective effects on activator protein-1 expression may explain the quantitative difference in insulin and phorbol ester action.
Chapman, S C
Multiple promoter elements are required for the stimulatory effect of insulin on human collagenase-1 gene transcription. Selective effects on activator protein-1 expression may explain the quantitative difference in insulin and phorbol ester action. [electronic resource] - The Journal of biological chemistry Jun 1999 - 18625-34 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.274.26.18625 doi
Animals
Binding Sites
CHO Cells
Chloramphenicol O-Acetyltransferase--genetics
Collagenases--genetics
Cricetinae
Genes, Reporter
HeLa Cells
Humans
Insulin--pharmacology
Matrix Metalloproteinase 1
Phorbol Esters--pharmacology
Phosphoenolpyruvate Carboxykinase (GTP)--genetics
Promoter Regions, Genetic
Protein Folding
Sequence Homology, Amino Acid
Signal Transduction--drug effects
Transcription Factor AP-1--metabolism
Transcription, Genetic--drug effects
Multiple promoter elements are required for the stimulatory effect of insulin on human collagenase-1 gene transcription. Selective effects on activator protein-1 expression may explain the quantitative difference in insulin and phorbol ester action. [electronic resource] - The Journal of biological chemistry Jun 1999 - 18625-34 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.274.26.18625 doi
Animals
Binding Sites
CHO Cells
Chloramphenicol O-Acetyltransferase--genetics
Collagenases--genetics
Cricetinae
Genes, Reporter
HeLa Cells
Humans
Insulin--pharmacology
Matrix Metalloproteinase 1
Phorbol Esters--pharmacology
Phosphoenolpyruvate Carboxykinase (GTP)--genetics
Promoter Regions, Genetic
Protein Folding
Sequence Homology, Amino Acid
Signal Transduction--drug effects
Transcription Factor AP-1--metabolism
Transcription, Genetic--drug effects