Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins.

Dehal, S S

Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Jun 1999 - 681-8 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0090-9556


Animals
Biotransformation
Catechols--metabolism
Cytochrome P-450 CYP2D6--biosynthesis
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System--biosynthesis
Estrogen Antagonists--pharmacokinetics
Humans
Hydroxylation
In Vitro Techniques
Liver--drug effects
Mixed Function Oxygenases--biosynthesis
Pentobarbital--pharmacology
Protein Binding
Rats
Rats, Sprague-Dawley
Tamoxifen--analogs & derivatives