SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.

Nielsen, E O

SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity. [electronic resource] - The Journal of pharmacology and experimental therapeutics Jun 1999 - 1492-501 p. digital

Publication Type: Journal Article

0022-3565


Animals
Binding Sites
Binding, Competitive
Cell Membrane--metabolism
Cells, Cultured
Cerebral Cortex--physiology
Electroshock
Excitatory Amino Acid Antagonists--pharmacology
Glycine--metabolism
Isoquinolines--chemistry
Kainic Acid--metabolism
Kinetics
Male
Membrane Potentials--drug effects
Mice
Mice, Inbred Strains
Molecular Structure
Neurons--drug effects
Neuroprotective Agents--pharmacology
Patch-Clamp Techniques
Pipecolic Acids--pharmacokinetics
Pyrroles--chemistry
Quinoxalines--pharmacology
Rats
Rats, Wistar
Receptors, AMPA--antagonists & inhibitors
Seizures--physiopathology
Stereoisomerism
Tetrahydroisoquinolines
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid--metabolism
gamma-Aminobutyric Acid--metabolism