Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785).

Discafani, C M

Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785). [electronic resource] - Biochemical pharmacology Apr 1999 - 917-25 p. digital

Publication Type: Journal Article

0006-2952

10.1016/s0006-2952(98)00356-6 doi


Animals
Antineoplastic Agents--chemical synthesis
Cell Cycle--drug effects
Cell Division--drug effects
Drug Screening Assays, Antitumor
Enzyme Inhibitors--chemical synthesis
ErbB Receptors--antagonists & inhibitors
Female
Mice
Mice, Nude
Models, Molecular
Neoplasm Transplantation
Neoplasms, Experimental--drug therapy
Phosphorylation--drug effects
Quinazolines--chemical synthesis
Tumor Cells, Cultured