Insertion of the Asp-Ser/Phe sequence in the P' position of hirutonin provides molecules having both antithrombin and disintegrin activity.

Leblond, L

Insertion of the Asp-Ser/Phe sequence in the P' position of hirutonin provides molecules having both antithrombin and disintegrin activity. [electronic resource] - Thrombosis research Feb 1999 - 171-81 p. digital

Publication Type: Journal Article

0049-3848

10.1016/s0049-3848(98)00182-0 doi


Animals
Antithrombins--chemistry
Cell Adhesion--drug effects
Disintegrins--chemistry
Hirudins--analogs & derivatives
Humans
Mice
Platelet Aggregation--drug effects
Platelet Aggregation Inhibitors--pharmacology
Protein Engineering
Structure-Activity Relationship
Tumor Cells, Cultured