Dual inhibition of phosphodiesterase 4 and matrix metalloproteinases by an (arylsulfonyl)hydroxamic acid template.

Groneberg, R D

Dual inhibition of phosphodiesterase 4 and matrix metalloproteinases by an (arylsulfonyl)hydroxamic acid template. [electronic resource] - Journal of medicinal chemistry Feb 1999 - 541-4 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm980567e doi


3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors
Animals
Cyclic Nucleotide Phosphodiesterases, Type 4
Fibroblasts--enzymology
Gelatinases--antagonists & inhibitors
Guinea Pigs
Hydroxamic Acids--chemical synthesis
Macrophages--enzymology
Matrix Metalloproteinase 1
Matrix Metalloproteinase 2
Matrix Metalloproteinase Inhibitors
Metalloendopeptidases--antagonists & inhibitors
Phosphodiesterase Inhibitors--chemical synthesis
Protease Inhibitors--chemical synthesis
Structure-Activity Relationship
Sulfones--chemical synthesis