gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. [electronic resource]
Producer: 19990318Description: 5791-6 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Animals
- Antigens, Surface -- genetics
- Binding Sites
- Bone Marrow Cells -- immunology
- Calcium -- metabolism
- Cells, Cultured
- Exocytosis
- Immunoglobulin E -- physiology
- Intracellular Signaling Peptides and Proteins
- Mast Cells -- immunology
- Membrane Glycoproteins -- genetics
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Protein Phosphatase 1
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases -- chemistry
- Receptors, IgE -- antagonists & inhibitors
- Receptors, Immunologic
- SH2 Domain-Containing Protein Tyrosine Phosphatases
- Sequence Homology, Amino Acid
- Tyrosine -- antagonists & inhibitors
- src Homology Domains
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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