Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. [electronic resource]
Producer: 19981224Description: 581-91 p. digitalISSN:- 1097-2765
- Animals
- Apoptosis -- drug effects
- Breast Neoplasms -- genetics
- CDC2 Protein Kinase -- antagonists & inhibitors
- CDC2-CDC28 Kinases
- Cell Line
- Cyclin B -- metabolism
- Cyclin B1
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases -- genetics
- Cyclins -- genetics
- DNA Fragmentation
- Fibroblasts
- Flow Cytometry
- Humans
- Kinetin
- Mice
- Oligonucleotides, Antisense -- genetics
- Paclitaxel -- pharmacology
- Protein Serine-Threonine Kinases -- genetics
- Purines -- pharmacology
- Receptor, ErbB-2 -- genetics
- Transfection
- Tumor Cells, Cultured
- Up-Regulation -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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