A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. [electronic resource]
Producer: 19980122Description: 85-92 p. digitalISSN:- 0270-7306
- Alkyl and Aryl Transferases -- antagonists & inhibitors
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Carcinoma -- drug therapy
- Cell Cycle -- drug effects
- Enzyme Inhibitors -- pharmacology
- Farnesyltranstransferase
- Female
- Genes, ras
- Humans
- Mammary Neoplasms, Experimental -- drug therapy
- Mammary Tumor Virus, Mouse
- Methionine -- analogs & derivatives
- Mice
- Mice, Transgenic
- Salivary Gland Neoplasms -- drug therapy
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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