The catalytic domain of pp56(lck), but not its regulatory domain, is sufficient for inducing IL-2 production. [electronic resource]
Producer: 19961213Description: 3775-82 p. digitalISSN:- 0022-1767
- Allosteric Site
- Binding Sites
- Biological Transport
- Calcium -- metabolism
- Catalysis
- DNA-Binding Proteins -- physiology
- Gene Expression Regulation, Leukemic -- drug effects
- Humans
- Interleukin-2 -- biosynthesis
- Ionomycin -- pharmacology
- Ionophores -- pharmacology
- Leukemia-Lymphoma, Adult T-Cell -- pathology
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- NFATC Transcription Factors
- Neoplasm Proteins -- physiology
- Nuclear Proteins
- Peptide Fragments -- pharmacology
- Promoter Regions, Genetic
- Receptors, Antigen, T-Cell -- physiology
- Signal Transduction -- drug effects
- Structure-Activity Relationship
- T-Lymphocytes -- drug effects
- Tetradecanoylphorbol Acetate -- pharmacology
- Transcription Factors -- physiology
- Transcriptional Activation
- Tumor Cells, Cultured
- src-Family Kinases -- chemistry
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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