Abnormal regulation of the LDL-R and HMG CoA reductase genes in subjects with familial hypercholesterolemia with the "French Canadian mutation". [electronic resource]
Producer: 19961213Description: 103-17 p. digitalISSN:- 0021-9150
- Anticholesteremic Agents -- pharmacology
- Canada -- epidemiology
- Cells, Cultured
- Enzyme Induction
- Enzyme Inhibitors -- pharmacology
- Ethnicity -- genetics
- Female
- Fibroblasts -- metabolism
- France -- ethnology
- Gene Expression Regulation -- drug effects
- Haploidy
- Humans
- Hydroxymethylglutaryl CoA Reductases -- genetics
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Hyperlipoproteinemia Type II -- drug therapy
- Lipoproteins, LDL -- metabolism
- Lovastatin -- pharmacology
- Male
- Prevalence
- RNA, Messenger -- biosynthesis
- Receptors, LDL -- genetics
- Sequence Deletion
- Transcription, Genetic
- Treatment Failure
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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