Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes. [electronic resource]
Producer: 19960910Description: 212-8 p. digitalISSN:- 0270-9139
- Acetylcysteine -- pharmacology
- Animals
- Biotransformation
- Cell Membrane -- drug effects
- Cysteine -- pharmacology
- Cystine -- pharmacology
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System -- metabolism
- Cytoskeleton -- drug effects
- Dexamethasone -- pharmacology
- Diterpenes -- metabolism
- Diterpenes, Clerodane
- Female
- Glutathione -- metabolism
- Liver -- drug effects
- Male
- Mixed Function Oxygenases -- metabolism
- Phytotherapy
- Plant Extracts -- metabolism
- Rats
- Rats, Sprague-Dawley
- Spiro Compounds -- metabolism
- Troleandomycin -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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