Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. [electronic resource]
Producer: 19930909Description: 493-501 p. digitalISSN:- 0006-2952
- Acetaminophen -- toxicity
- Acetone
- Aminopyrine N-Demethylase -- biosynthesis
- Animals
- Aryl Hydrocarbon Hydroxylases
- Benzoflavones
- Benzoquinones -- metabolism
- Biotransformation -- drug effects
- Caffeine -- pharmacology
- Chemical and Drug Induced Liver Injury
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- biosynthesis
- Dexamethasone
- Drug Interactions
- Enzyme Activation
- Female
- Imines -- metabolism
- Isoenzymes -- metabolism
- Kinetics
- Liver Diseases -- enzymology
- Mice
- Microsomes, Liver -- drug effects
- Oxidoreductases, N-Demethylating -- biosynthesis
- Phenobarbital
- beta-Naphthoflavone
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Publication Type: Comparative Study; Journal Article
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