Activation by peptidases and cytotoxicity of 2-(L-alpha-aminoacyl) prodrugs of methotrexate. [electronic resource]
Producer: 19940310Description: 457-60 p. digitalISSN:- 0065-2598
- Acylation
- Amino Acids
- Aminopeptidases -- metabolism
- Animals
- Bacillus -- enzymology
- CD13 Antigens
- Cell Survival -- drug effects
- Endopeptidases -- metabolism
- Folic Acid Antagonists
- Kidney -- enzymology
- Lacticaseibacillus casei -- enzymology
- Leukemia L1210
- Methotrexate -- analogs & derivatives
- Mice
- Prodrugs -- metabolism
- Pyroglutamyl-Peptidase I -- metabolism
- Structure-Activity Relationship
- Swine
- Tumor Cells, Cultured
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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