Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. [electronic resource]
Producer: 19801120Description: 474-81 p. digitalISSN:- 0006-291X
- Amides -- pharmacology
- Animals
- Cell Nucleus -- drug effects
- Diabetes Mellitus, Experimental -- chemically induced
- Islets of Langerhans -- drug effects
- Male
- NAD -- metabolism
- NAD+ Nucleosidase -- antagonists & inhibitors
- Niacinamide -- pharmacology
- Picolinic Acids -- pharmacology
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases -- metabolism
- Proinsulin -- biosynthesis
- Rats
- Streptozocin -- antagonists & inhibitors
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Publication Type: Journal Article
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