Structural and functional evidence for citicoline binding and modulation of 20S proteasome activity: Novel insights into its pro-proteostatic effect. [electronic resource]
Producer: 20201201Description: 113977 p. digitalISSN:- 1873-2968
- Allosteric Regulation
- Amino Acid Sequence
- Binding Sites
- Cell Line, Tumor
- Cytidine Diphosphate Choline -- chemistry
- Gene Expression
- Humans
- Kinetics
- Molecular Docking Simulation
- Neurons -- drug effects
- Neuroprotective Agents -- chemistry
- Nootropic Agents -- chemistry
- Proteasome Endopeptidase Complex -- chemistry
- Proteasome Inhibitors -- chemistry
- Protein Binding
- Protein Conformation, alpha-Helical
- Protein Conformation, beta-Strand
- Protein Interaction Domains and Motifs
- Proteostasis -- drug effects
- Recombinant Proteins -- chemistry
- Sequence Alignment
- Sequence Homology, Amino Acid
- Substrate Specificity
- Thermodynamics
- alpha-Synuclein -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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