Pyridazino[1,6-b]quinazolinones as new anticancer scaffold: Synthesis, DNA intercalation, topoisomerase I inhibition and antitumor evaluation in vitro and in vivo. [electronic resource]
Producer: 20210302Description: 103814 p. digitalISSN:- 1090-2120
- Animals
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Cattle
- Cell Cycle -- drug effects
- Cell Proliferation -- drug effects
- DNA -- chemistry
- DNA Topoisomerases, Type I -- metabolism
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Humans
- Molecular Docking Simulation
- Molecular Structure
- Quinazolinones -- chemical synthesis
- Structure-Activity Relationship
- Topoisomerase I Inhibitors -- chemical synthesis
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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