A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. [electronic resource]
Producer: 20200227Description: 5681 p. digitalISSN:- 2041-1723
- Animals
- Autophagy -- genetics
- Carcinogenesis -- genetics
- Cell Proliferation
- Centrosome
- Colitis
- Colonic Neoplasms -- pathology
- Colorectal Neoplasms -- genetics
- Female
- Frameshift Mutation
- Inflammasomes
- Inflammation -- genetics
- Lipopolysaccharides -- adverse effects
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- NLR Family, Pyrin Domain-Containing 3 Protein
- Sepsis
- Starvation
- Toll-Like Receptor 4 -- metabolism
- Tumor Suppressor Proteins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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