A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma. [electronic resource]
Producer: 20201110Description: 1150-1163 p. digitalISSN:- 1523-5866
- Anilides
- Animals
- Biphenyl Compounds
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cerebellar Neoplasms -- drug therapy
- Drug Resistance, Neoplasm -- genetics
- Hedgehog Proteins -- drug effects
- High-Throughput Screening Assays
- Histone Deacetylase Inhibitors -- pharmacology
- Hydroxamic Acids -- pharmacology
- Inhibitory Concentration 50
- Medulloblastoma -- drug therapy
- Mice
- Proteins -- genetics
- Pyridines
- Repressor Proteins -- genetics
- Signal Transduction
- Smoothened Receptor -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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