Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription. [electronic resource]
Producer: 20200228ISSN:- 2050-084X
- Animals
- Ataxin-3 -- metabolism
- Cell Line
- DNA Repair
- DNA Repair Enzymes -- metabolism
- DNA-Directed RNA Polymerases -- metabolism
- Humans
- Huntingtin Protein -- genetics
- Mice, Transgenic
- Mutant Proteins -- genetics
- Peptide Fragments -- metabolism
- Phosphotransferases (Alcohol Group Acceptor) -- metabolism
- Protein Binding
- Protein Multimerization
- Repressor Proteins -- metabolism
- Sialoglycoproteins -- metabolism
- Transcription, Genetic
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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