L-securinine inhibits cell growth and metastasis of human androgen-independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 apoptotic pathways. [electronic resource]
Producer: 20200706ISSN:- 1573-4935
- Antineoplastic Agents, Phytogenic -- pharmacology
- Apoptosis -- drug effects
- Azepines -- pharmacology
- Caspase 3 -- genetics
- Caspase 9 -- genetics
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Heterocyclic Compounds, Bridged-Ring -- pharmacology
- Humans
- Lactones -- pharmacology
- MAP Kinase Kinase 1 -- genetics
- MAP Kinase Kinase 2 -- genetics
- Male
- Mitochondria -- drug effects
- Mitogen-Activated Protein Kinase 1 -- genetics
- Mitogen-Activated Protein Kinase 3 -- genetics
- PAX2 Transcription Factor -- genetics
- Piperidines -- pharmacology
- Prostatic Neoplasms, Castration-Resistant -- drug therapy
- Receptor, Angiotensin, Type 1 -- genetics
- STAT3 Transcription Factor -- genetics
- Signal Transduction
- bcl-2-Associated X Protein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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