Targeting IDH1-Mutated Malignancies with NRF2 Blockade. [electronic resource]
Producer: 20200615Description: 1033-1041 p. digitalISSN:- 1460-2105
- Animals
- Antineoplastic Agents -- pharmacology
- Antioxidants -- pharmacology
- Cell Line, Tumor
- Disease Models, Animal
- Genes, Reporter
- Genetic Predisposition to Disease
- Humans
- Isocitrate Dehydrogenase -- genetics
- Mice
- Models, Biological
- Molecular Targeted Therapy
- Mutation
- NF-E2-Related Factor 2 -- antagonists & inhibitors
- Neoplasms -- drug therapy
- Oxidation-Reduction
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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