Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway. [electronic resource]
Producer: 20200507Description: 843-870 p. digitalISSN:- 1554-8635
- Animals
- Autophagy -- drug effects
- Capillary Permeability -- drug effects
- Cells, Cultured
- Diabetes Mellitus, Experimental -- complications
- Diabetic Angiopathies -- metabolism
- Down-Regulation -- drug effects
- Endothelium, Vascular -- drug effects
- Gene Expression Regulation -- drug effects
- HEK293 Cells
- Hedgehog Proteins -- drug effects
- Human Umbilical Vein Endothelial Cells
- Humans
- Hyperglycemia -- complications
- Metformin -- pharmacology
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Retina -- drug effects
- Signal Transduction -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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