RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling. [electronic resource]
Producer: 20190510Description: 284-291 p. digitalISSN:- 1546-170X
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Heterocyclic Compounds, 2-Ring -- pharmacology
- Humans
- Mutation -- genetics
- Phosphorylation -- drug effects
- Protein Multimerization
- Proto-Oncogene Proteins B-raf -- genetics
- Signal Transduction
- Sulfonamides -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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