Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells. [electronic resource]
Producer: 20191203Description: 3047-3058.e4 p. digitalISSN:- 2211-1247
- Acids -- metabolism
- Animals
- Cell Line, Tumor
- Energy Metabolism -- drug effects
- Humans
- Intracellular Space -- metabolism
- Lactic Acid -- metabolism
- Male
- Metformin -- pharmacology
- Mice, Inbred C57BL
- Monocarboxylic Acid Transporters -- antagonists & inhibitors
- Muscle Proteins -- antagonists & inhibitors
- NAD -- metabolism
- Neoplasms -- metabolism
- Reserpine -- analogs & derivatives
- Symporters -- antagonists & inhibitors
- Synthetic Lethal Mutations
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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