Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease. [electronic resource]
Producer: 20191105Description: 1359-1373 p. digitalISSN:- 1432-1440
- Animals
- Brain -- metabolism
- Disease Models, Animal
- Fibroblasts -- drug effects
- Gangliosides -- metabolism
- HEK293 Cells
- Hexosaminidase A -- metabolism
- Humans
- Lysosomes -- metabolism
- Mice
- Mice, Knockout
- Progranulins -- genetics
- RAW 264.7 Cells
- Recombinant Proteins -- pharmacology
- Tay-Sachs Disease -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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