Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL. [electronic resource]
Producer: 20190114Description: 965 p. digitalISSN:- 1471-2407
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Breast Neoplasms -- drug therapy
- CASP8 and FADD-Like Apoptosis Regulating Protein -- metabolism
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- genetics
- Female
- Forkhead Box Protein O3 -- biosynthesis
- Gene Expression -- drug effects
- Genes, erbB-2
- Humans
- Lapatinib -- pharmacology
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- TNF-Related Apoptosis-Inducing Ligand -- pharmacology
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Publication Type: Journal Article
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