KU70 Inhibition Impairs Both Non-Homologous End Joining and Homologous Recombination DNA Damage Repair Through SHP-1 Induced Dephosphorylation of SIRT1 in T-Cell Acute Lymphoblastic Leukemia (T-ALL) [corrected]. [electronic resource]
Producer: 20181023Description: 2111-2123 p. digitalISSN:- 1421-9778
- Animals
- Apoptosis
- Ataxia Telangiectasia Mutated Proteins -- metabolism
- Cell Cycle Checkpoints
- DNA Breaks, Double-Stranded
- DNA End-Joining Repair
- Humans
- Jurkat Cells
- Ku Autoantigen -- antagonists & inhibitors
- Leukemia-Lymphoma, Adult T-Cell -- drug therapy
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Phosphorylation
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 -- antagonists & inhibitors
- RNA Interference
- RNA, Small Interfering -- metabolism
- Rad51 Recombinase -- metabolism
- Recombinational DNA Repair
- Sirtuin 1 -- metabolism
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Publication Type: Journal Article
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