Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. [electronic resource]
Producer: 20190415Description: 373-381 p. digitalISSN:- 1090-2120
- Adaptor Proteins, Signal Transducing
- Antineoplastic Agents -- chemical synthesis
- Click Chemistry
- Cyclin-Dependent Kinase 9 -- antagonists & inhibitors
- Drug Discovery
- Flavanones -- chemical synthesis
- Humans
- MCF-7 Cells
- Molecular Docking Simulation
- Neoplasms -- drug therapy
- Peptide Hydrolases -- metabolism
- Protein Kinase Inhibitors -- chemical synthesis
- Proteolysis -- drug effects
- Ubiquitin-Protein Ligases
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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