ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. [electronic resource]
Producer: 20190114Description: 1744806918801224 p. digitalISSN:- 1744-8069
- Adaptor Proteins, Signal Transducing -- antagonists & inhibitors
- Animals
- Animals, Newborn
- Antineoplastic Agents -- adverse effects
- Cell Survival -- drug effects
- Cells, Cultured
- Cerebral Cortex -- cytology
- Disease Models, Animal
- Enzyme Inhibitors -- therapeutic use
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Green Fluorescent Proteins -- genetics
- HEK293 Cells
- Humans
- Hyperalgesia -- drug therapy
- Immunoprecipitation
- Male
- Mice
- Mice, Inbred C57BL
- Neoplasms -- drug therapy
- Neuralgia -- chemically induced
- Neurons
- Nitric Oxide Synthase Type I -- antagonists & inhibitors
- Paclitaxel -- adverse effects
- Pain Threshold -- drug effects
- Rats
- Transfection
- Xenograft Model Antitumor Assays -- methods
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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